SrasV1, Main, Exploration, bibRecord, 003B89

Amino acid substitutions in the S2 region enhance severe acute respiratory syndrome coronavirus infectivity in rat angiotensin-converting enzyme 2-expressing cells

Identifieur interne : 003B89 ( Main/Exploration ); précédent : 003B88; suivant : 003B90

Amino acid substitutions in the S2 region enhance severe acute respiratory syndrome coronavirus infectivity in rat angiotensin-converting enzyme 2-expressing cells

Auteurs : Shuetsu Fukushi [Japon] ; Tetsuya Mizutani [Japon] ; Kouji Sakai [Japon] ; Masayuki Saijo [Japon] ; Fumihiro Taguchi [Japon] ; Masaru Yokoyama [Japon] ; Ichiro Kurane [Japon] ; Shigeru Morikawa [Japon]

Source :

Journal of virology [ 0022-538X ] ; 2007.

RBID : Pascal:07-0486461

Descripteurs français

KwdFr :
- Animaux, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (), Glycoprotéines membranaires (génétique), Humains, Lignée cellulaire, Peptidyl-Dipeptidase A (métabolisme), Protéines de l'enveloppe virale (), Protéines de l'enveloppe virale (génétique), Rats, Réplication virale (génétique), Substitution d'acide aminé, Virus du SRAS (génétique), Virus du SRAS (physiologie).
MESH :
- génétique : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Réplication virale, Virus du SRAS.
- métabolisme : Peptidyl-Dipeptidase A.
- physiologie : Virus du SRAS.
Pascal (Inist)
- Animaux, Coronavirus rat, Aigu, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires, Humains, Lignée cellulaire, Pouvoir infectant, In vitro, Protéines de l'enveloppe virale, Rats, Substitution d'acide aminé, Virologie, Angiotensin converting enzyme 2.

English descriptors

KwdEn :
- Acute, Amino Acid Substitution, Animals, Cell Line, Humans, In vitro, Infectivity, Membrane Glycoproteins (chemistry), Membrane Glycoproteins (genetics), Peptidyl-Dipeptidase A (metabolism), Rat coronavirus, Rats, SARS Virus (genetics), SARS Virus (physiology), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (chemistry), Viral Envelope Proteins (genetics), Virology, Virus Replication (genetics).
MESH :
- chemical , chemistry : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , genetics : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , metabolism : Peptidyl-Dipeptidase A.
- genetics : SARS Virus, Virus Replication.
- physiology : SARS Virus.
- Amino Acid Substitution, Animals, Cell Line, Humans, Rats, Spike Glycoprotein, Coronavirus.

Abstract

To clarify the molecular basis of severe acute respiratory syndrome coronavirus (SARS-CoV) adaptation to different host species, we serially passaged SARS-CoV in rat angiotensin-converting enzyme 2 (ACE2)-express-ing cells. After 15 passages, the virus (Rat-P15) came to replicate effectively in rat ACE2-expressing cells. Two amino acid substitutions in the S2 region were found on the Rat-P15 S gene. Analyses of the infectivity of the pseudotype-bearing S protein indicated that the two substitutions in the S2 region, especially the S950F substitution, were responsible for efficient infection. Therefore, virus adaptation to different host species can be induced by amino acid substitutions in the S2 region.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2045470

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute</term>
<term>Amino Acid Substitution</term>
<term>Animals</term>
<term>Cell Line</term>
<term>Humans</term>
<term>In vitro</term>
<term>Infectivity</term>
<term>Membrane Glycoproteins (chemistry)</term>
<term>Membrane Glycoproteins (genetics)</term>
<term>Peptidyl-Dipeptidase A (metabolism)</term>
<term>Rat coronavirus</term>
<term>Rats</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (physiology)</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Envelope Proteins (chemistry)</term>
<term>Viral Envelope Proteins (genetics)</term>
<term>Virology</term>
<term>Virus Replication (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires ()</term>
<term>Glycoprotéines membranaires (génétique)</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Peptidyl-Dipeptidase A (métabolisme)</term>
<term>Protéines de l'enveloppe virale ()</term>
<term>Protéines de l'enveloppe virale (génétique)</term>
<term>Rats</term>
<term>Réplication virale (génétique)</term>
<term>Substitution d'acide aminé</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (physiologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peptidyl-Dipeptidase A</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term>
<term>Virus Replication</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéines membranaires</term>
<term>Protéines de l'enveloppe virale</term>
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<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Substitution</term>
<term>Animals</term>
<term>Cell Line</term>
<term>Humans</term>
<term>Rats</term>
<term>Spike Glycoprotein, Coronavirus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term>
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<term>Glycoprotéines membranaires</term>
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<term>Lignée cellulaire</term>
<term>Pouvoir infectant</term>
<term>In vitro</term>
<term>Protéines de l'enveloppe virale</term>
<term>Rats</term>
<term>Substitution d'acide aminé</term>
<term>Virologie</term>
<term>Angiotensin converting enzyme 2</term>
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<front><div type="abstract" xml:lang="en">To clarify the molecular basis of severe acute respiratory syndrome coronavirus (SARS-CoV) adaptation to different host species, we serially passaged SARS-CoV in rat angiotensin-converting enzyme 2 (ACE2)-express-ing cells. After 15 passages, the virus (Rat-P15) came to replicate effectively in rat ACE2-expressing cells. Two amino acid substitutions in the S2 region were found on the Rat-P15 S gene. Analyses of the infectivity of the pseudotype-bearing S protein indicated that the two substitutions in the S2 region, especially the S950F substitution, were responsible for efficient infection. Therefore, virus adaptation to different host species can be induced by amino acid substitutions in the S2 region.</div>
</front>
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<name sortKey="Kurane, Ichiro" sort="Kurane, Ichiro" uniqKey="Kurane I" first="Ichiro" last="Kurane">Ichiro Kurane</name>
<name sortKey="Mizutani, Tetsuya" sort="Mizutani, Tetsuya" uniqKey="Mizutani T" first="Tetsuya" last="Mizutani">Tetsuya Mizutani</name>
<name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name>
<name sortKey="Saijo, Masayuki" sort="Saijo, Masayuki" uniqKey="Saijo M" first="Masayuki" last="Saijo">Masayuki Saijo</name>
<name sortKey="Sakai, Kouji" sort="Sakai, Kouji" uniqKey="Sakai K" first="Kouji" last="Sakai">Kouji Sakai</name>
<name sortKey="Taguchi, Fumihiro" sort="Taguchi, Fumihiro" uniqKey="Taguchi F" first="Fumihiro" last="Taguchi">Fumihiro Taguchi</name>
<name sortKey="Yokoyama, Masaru" sort="Yokoyama, Masaru" uniqKey="Yokoyama M" first="Masaru" last="Yokoyama">Masaru Yokoyama</name>
</country>
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   |texte=   Amino acid substitutions in the S2 region enhance severe acute respiratory syndrome coronavirus infectivity in rat angiotensin-converting enzyme 2-expressing cells
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Amino acid substitutions in the S2 region enhance severe acute respiratory syndrome coronavirus infectivity in rat angiotensin-converting enzyme 2-expressing cells

Amino acid substitutions in the S2 region enhance severe acute respiratory syndrome coronavirus infectivity in rat angiotensin-converting enzyme 2-expressing cells

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